Cell cycle and apoptosis in PER.C6® cultures
نویسندگان
چکیده
Background PER.C6 is a human cell line designed for virus production, which was immortalized by transformation with adenoviral E1A and E1B genes. Expression of E1A is known to inhibit negative regulators of cell cycle and E1B protein function analogously to an apoptosis inhibitor. As changes in cell cycle and apoptosis are likely to affect cell’s ability for viral infection and propagation, the study of these parameters in PER.C6 cultures is essential to develop optimum virus production processes.
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عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2013